基于核酸治疗的药物的前景Pharmaceutical Perspectives of Nucleic acid-based Therapeutics umd mobi chm 夸克云 免费 azw3 下载 pdf

Pharmaceutical Perspectives of Nucleic Acid-Based Therapy presents a comprehensive account of gene therapy, from development in the laboratory to clinical applications, with an emphasis on cancer and cardiovascular and autoimmune diseases. Internationally acclaimed scientists discuss the potential use of lipids, peptides and polymers for the in vivo delivery of nucleic acids, the genesis of structure-synthesis-function interrelationships and the evolutionary approaches of these gene carriers. The book also addresses the influence of a viable gene expression system on disease by controlling gene regulation, tran*ion, translation and replication.

Univ. of Tennessee, Memphis. Presents a comprehensive account of design and modulation of gene expression and nucleic acid delivery systems. Includes the possible use of lipids, structure-synthesis-function relationship, and the use of DNA and devices for gene delivery. Contains color plates and halftone illustrations. For research scientists.

List of color plates

List of figures

List of tables

List of contributors

Foreword

Preface

1 Basic components of gene expression plasmids

2 Inducible gene expression strategies in gene therapy

3 Modulation of gene expression by antisense oligonucleotides

4 Ribozymes as therapeutic agents and genetic tools

5 Peptide nucleic acids (PNA) binding-mediated target gene transcription

6 Aptamers for controlling gene expression

7 Enzymes acting on DNA breaks and its relevance in nucleic acid-based therapy

8 Compaction and condensation of DNA

9 Structure, dispersion stability and dynamics of DNA and polycation complexes

10 Structure and structure-activity correlations of cationic lipid/DNA complexes: supramolecular assembly and gene delivery

11 Cellular uptake, metabolic stability and nuclear translocation of nucleic acids

12 Nucleocytoplasmic trafficking

13 Optimizing RNA export for transgene expression

14 Naked plasmid DNA delivery of a therapeutic protein

15 Cationic lipid-based gene delivery

16 Peptide-based gene delivery systems

17 Cationic and non-condensing polymer-based gene delivery

18 Device-mediated gene delivery

19 Basic pharmaeokinetics of oligonucleotides and genes

20 Interstitial transport of macromolecules: implication for nucleic acid delivery in solid tumors

21 Hepatic delivery of nucleic acids using hydrodynamics-based procedure

22 Role of CpG motifs in immunostimulation and gene expression

23 Local cardiovascular gene therapy

24 Gene therapy for cardiovascular disease

25 Gene therapy for the prevention of autoimmune diabetes List of color plates

Ram Mahato is at the University of Tennessee in Memphis, USA and Sung Wan Kim is at the University of Utah, USA.

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书籍介绍

Emphasizing its uses in cancer and cardiovascular and autoimmune diseases, Pharmaceutical Perspectives of Nucleic Acid-Based Therapy presents a comprehensive account of gene therapy, from development in the laboratory to clinical applications. Internationally acclaimed scientists discuss the potential use of lipids, peptides and polymers for the in vivo delivery of nucleic acids, the genesis of structure-synthesis-function interrelationships and the evolutionary approaches of these gene carriers. The book also addresses the influence of a viable gene expression system on disease by controlling gene regulation, transcription, translation and replication.